His introduction to the test arena has been far from ideal, Super Rugby commitments meaning he has had less than a week to prepare a squad lacking injured first choices Schalk Burger, Juan Smith, Andries Bekker and Duane Vermeulen.
Meyer wanted veteran Fourie du Preez at halfback, but a heart-to-heart chat in Pretoria last week revealed that the player once the best in his position in the world was not battle-ready after a 10-week lay-off from Japanese club rugby.
While a Burger-Smith-Vermeulen back row would be a match for any test rivals, the absence of Bekker is the one that could be most dearly felt, as locks Eben Etzebeth and Juandre Kruger are both uncapped.
Although Meyer raves about 20-year-old Etzebeth, England must feel that South Africa-born Mouritz Botha and Geoff Parling could give them an edge come lineout time.
The man England coach Stuart Lancaster must fear most is South Africa five-eighths and goal-kicker extraordinaire Morne Steyn.
Northern Bulls pivot Steyn was leading scorer at the last World Cup, is top of the charts in the Super Rugby this season and can plant the ball between the posts from any distance or angle.
Flank Marcell Coetzee is the third Springbok debutant in the team.
England have chosen test newcomers in loose-head prop Joe Marler and blindside flank Tom Johnson and only five of the 2010 losers remain - wings Chris Ashton and Ben Foden, halfback Ben Youngs and front rowers Dylan Hartley and Dan Cole.
- AAP