The former Warriors captain warned his side needed to adapt better, after injuries forced both vice-captain Simon Mannering (neck) and hooker Issac Luke (ribs) to the sidelines early in the second half.
Luke clutched his ribs after converting the Warriors fourth try right on halftime and despite taking the field after the break, the Kiwis international lasted just three minutes before being replaced.
Mannering followed five minutes later, after being slow to get up after completing a tackle on Knights fullback Dylan Phythian.
The pair remain in doubt for next Friday night's clash against Melbourne Storm but the Warriors medical staff will assess the extent of both injuries in the next 48 hours.
With back-rower Bodene Thompson filling in at dummy-half in his first outing of the season and 18-year-old debutant Isaiah Papali'i replacing Mannering, the Warriors lacked organisation and stability in the middle.
"I don't think we adapted very well to both Issac and Simon going off the field because they hold our middle together so that's certainly a work-on for us," said Hoffman.
Coach Stephen Kearney was thrilled with Hoffman's contribution and the manner in which he stood tall in the absence of two of the side's forward leaders.
Despite losing the captaincy to Tuivasa-Sheck and being told his services are not required next season, Hoffman proved his commitment to the Warriors remained absolute.
"He had a wonderful performance today," said Kearney. "He came up with some really telling tackles and big runs. He and Roger both came up with some wonderful plays too but Ryan's effort was really good.
"That epitomises Hoff. Everyone keeps talking about him and the captaincy but he's a real pro and you saw that today."
