Afoa (19) is in line for his fourth NRL outing, coming back into the squad after he also turned out for the Junior Warriors in their 30-28 win over competition leader Penrith last weekend. Ben Matulino, Sam Lisone and centre Blake Ayshford make up the rest of the interchange bench.
Saturday's combatants sit just one point apart on the ladder, the Titans seventh on 23 points and the Warriors eighth on 22.
They both go into this week's vital encounter on the back of golden point extra time encounters, Shaun Johnson clinching the victory over Penrith with his stunning try while the Titans drew 18-18 with Cronulla on Monday night.
The Panthers' match was the Warriors' fourth golden point match in their last five games and their fifth this year, both NRL records in a season.
Despite the added workload, assistant coach Justin Morgan said the team's ability to see out matches as well as the improved defence had been encouraging.
"While we've been in a lot of tough battles lately it has been pleasing to see the way we've been able to finish strongly," he said.
"Our defence has also been much improved. We're not doing anything any differently there from what we've done all season but it has taken time for the new system to bed in with the players."