Nicoll-Klokstad impressed for the Cook Islands in last Saturday night's Pacific Test against Papua New Guinea while Vatuvei had a strong debut for Mate Ma'a Tonga in its win over Fiji Bati.
While Tuivasa-Sheck and Lisone eye landmark appearances this week, interchange prop Ben Matulino and second rower Bodene Thompson move within one game of milestones they're set to jointly reach next week against St George in Hamilton.
This week Matulino, again named on the bench, plays his 199th career game - all for the Warriors - while Thompson makes his 49th appearance for the club (the 134th of his NRL career).
The Warriors are 11th on the NRL table two points out of the top eight with a 4-5 win-loss record. The Panthers are 15th with a 2-7 record after losing their last five games.
The Warriors have lost their previous four away matches against the Panthers with their last win being a 30-16 victory in Penrith in 2012.
Warriors v Penrith Panthers
Pepper Stadium, Penrith
5.00pm (NZT), Saturday, May 13
Warriors
1 Roger Tuivasa-Sheck (C)
2 David Fusitu'a
3 Blake Ayshford
4 Solomone Kata
5 Ken Maumalo
6 Kieran Foran
7 Shaun Johnson
8 James Gavet
9 Issac Luke
10 Jacob Lillyman
11 Bodene Thompson
12 Ryan Hoffman
13 Simon Mannering
Interchange:
14 Nathaniel Roache
15 Sam Lisone
16 Ligi Sao
17 Ben Matulino
18 Manu Vatuvei
20 Mason Lino
21 Bunty Afoa
22 Charnze Nicoll-Klokstad
Coach | Stephen Kearney