The former All Black has made four appearances for the Roosters since returning to the club mid-season.
The Roosters, along with the loss of Williams, will be without Jake Friend following a concussion.
The defending premiers will be looking to bounce back from last week's humiliating 60-8 loss to the Rabbitohs.
Roosters coach Trent Robinson says his players are keen to redeem themselves.
"These guys don't run away from anything, they don't try to dismiss it without trying to improve," he said.
"It was a lesson sent our way so we needed to pick it up, take it, and then the focus has been from Monday about Friday's game."
"It's a memory now that we won't forget but it's no longer a weight."
- with news.com.au