Penrith prop Tim Grant loses his spot to Fifita, despite some good recent form and Kurt Gidley is back on the bench having missed last year's series because of injury.
At just 25, Jarryd Hayne is the most experienced player in the team with 16 appearances.
The Parramatta star will start at fullback for the first time since game three in 2010, having spent most of his Blues career on the wing.
Meanwhile, Darius Boyd is in doubt to play for Queensland after suffering a suspected high ankle sprain during Newcastle's loss to the Warriors. Boyd suffered the injury five minutes into the second half in Auckland when his left leg was trapped in a tackle.
He played on for about 10 more minutes before going off and later left the ground with the leg in a moon boot.
Newcastle team performance director Jeremy Hickmans said it was too early to say exactly how serious the injury was, with fullback Boyd to undergo scans after the Knights return to Newcastle today.
"It's looking like a high ankle sprain at the moment," he said.
"We'll know the extent of it when we get the scans tomorrow."
Asked about Boyd's chances of making the Origin opener, Hickmans said: "I wouldn't like to guess on that one.
"It's one of those [injuries] where, if there's not that much damage, he will be pretty close. If there is, he won't."
And Carney is likely to have his own individual source of motivation for the Sharks' clash against Souths tonight after missing a spot in Daley's team.
NSW team
Jarryd Hayne, Brett Morris, Michael Jennings, Josh Morris, Blake Ferguson, James Maloney, Mitchell Pearce, James Tamou, Robbie Farah, Paul Gallen (c), Luke Lewis, Ryan Hoffman, Greg Bird. Interchange: Anthony Watmough, Kurt Gidley, Andrew Fifita, Trent Merrin.
- AAP