Souths set up the win with a nearly flawless first half, completing 17 of 18 sets to take a 20-0 lead into the break on the back of a double to hooker Nathan Peats, filling in more than capably for Luke.
Inglis' replacement at the back, try-scoring machine Nathan Merritt, chimed in after 33 minutes, backing up a John Sutton line-break to score his 12th try of the season.
Not to be outdone, Souths' halves showed off in the second half, delighting the 29,863-strong crowd.
Rookie halfback Adam Reynolds ran circles around debutant Tigers winger Marika Koroibete to set up Dylan Farrell, while Sutton continued his hot form in the lead-up to Jason Clark's second-half four-pointer.
With Curtis Sironen ruled out for the rest of the season with a shoulder injury, Benji Marshall reverted to his five-eighth role while captain Robbie Farah played halfback.
The combination failed to generate many positive results in attack, although the pair did combine 13 minutes from fulltime when Marshall grounded a Farah grubber kick to score a consolation try.
After starting the weekend in eighth place, the Tigers slip to 10th following the loss.
-AAP