By the main break, the home side had forced more errors out of their opposition and enjoyed twice as many plays inside the opposition 20-metre line.
But last year's entertainers had nothing to show for it and were left frustrated by the rushing defensive line of the Sharks, who, by contrast, had no such trouble crossing the stripe.
Halfback Chad Townsend grubbered through for halves partner James Maloney in the 17th minute, before Sosaia Feki finished off a simple left-side shift for a decisive try in the 37th.
Not even the return of several troops, headed by skipper Matt Moylan, and backline flyers Tyrone Peachey and Waqa Blake, could inspire the Panthers out of their rut.
Any chance of a Panthers fightback after halftime quickly dissipated, with Bird and Gallen's double-blow, meaning serious questions must now be asked of the pre-season favourites.
On an afternoon when there were even contributions across the board, Sharks fullback Valentine Holmes was arguably his side's best, with a team-high 166 metres and three tackle busts.