On the flip side of these injuries, several notable players are back in action and deserve a look in for your team this weekend - they include Anthony Watmough, Andrew Fifita and Tim Simona.
Issak Luke is also back starting for the Rabbitohs and is worth watching to see if this results in a return to 2013 form.
Another note on playing time involves Broncos hooker Andrew McCullough who has been a valuable source of points all season. After McCullough suffered a knee injury last month, his replacement Jake Granville showed strong form and, as a result, has forced his way into increased minutes for the Broncos. This means McCullough is no longer an 80-minute player and no longer a top five option in the front row.
This weekend's matchups to exploit involve expected great days for players from the Knights, Sea Eagles, Sharks, Cowboys, Tigers and Warriors.
The Knights face up against a Titans side that is conceding a huge amount of fantasy points every week. Look to Kurt Gidley ($333,000) and Dane Gagai ($327,000) as top options this weekend.
The Sea Eagles come up against the Dragons on Monday night where I'm expecting big games from the likes of Jamie Lyon ($596,000), Jorge Taufua ($457,000), Jamie Buhrer ($257,000), Anthony Watmough ($367,000) and Matt Ballin ($432,000).
The Sharks and Cowboys face up in a fantasy dream on Friday night - the Cowboys squad looks especially potent with Jonathan Thurston ($334,000), Tariq Sims ($220,000) and Kane Linnett ($396,000) the picks of their squad.
From the Tigers and Warriors, your best options are Robbie Farah ($328,000), Aaron Woods ($202,000), Pat Richards ($133,000), Konrad Hurrell ($388,000), Simon Mannering ($291,000) and Nathan Friend ($393,000). Please note that Warriors fullback Sam Tomkins is in doubt to play against the Broncos and might be worth benching as a result.
Top Pick:
Kurt Gidley, Knights
Value Pick:
Pat Richards, Tigers
On the bench:
Paul Gallen, Sharks (out 2-3 weeks)
Daniel Tupou, Roosters (out 6 weeks)
Josh Mansour, Panthers (unlikely to play)
Tyrone Peachey, Panthers (out for season)
Trent Merrin, Dragons (out 2 weeks)
Sam Tomkins, Warriors (in doubt to play)