"It's a really important trial for us and we certainly want to win it," McFadden said.
"We've picked the strongest side we can, which was always the plan this week.
"Apart from Manu and Nathan, we're also without Simon, Jacob and Konrad. They are getting close but aren't quite right this week so we won't rush them in."
Vatuvei and Friend are the only NRL Nines players not involved. Indeed the starting line-up to face the Panthers comprises 12 Nines players plus Leuluai, who will start at hooker and will also captain the side in Mannering's absence. Four more Nines representatives are on an extended bench of 11 players.
Of the players used in last Saturday night's 12-22 loss to Gold Coast, Allwood, Marata Niukore, Api Pewhairangi, Nathaniel Roache, Raymond Faitala-Mariner, John Palavi and Albert Vete are on the bench.
Warriors: Sam Tomkins; Ken Maumalo, Ngani Laumape, Solomone Kata, Tuimoala Lolohea; Chad Townsend, Shaun Johnson; Suaia Matagi, Thomas Leuluai (c), Ben Matulino; Bodene Thompson, Ryan Hoffman; Ben Henry. Interchange: Matt Allwood, Marata Niukore, Api Pewhairangi, Sam Lisone, Nathaniel Roache, Sione Lousi, Raymond Faitala-Mariner, John Palavi, Albert Vete, Sam Rapira, Jazz Tevaga.