Nightingale's absence opens the door for Roger Tuivasa-Sheck to slot in on the wing, but Kearney could be tempted to play him in his preferred position of fullback and switch Manly's Peta Hiku to the flank.
Whare's misfortune provides Kearney with perhaps his biggest selection conundrum, and he may be tempted to take a gamble on 20-year-old Warriors centre Solomone Kata over Cronulla's Gerard Beale.
Fellow Warriors midfielder Konrad Hurrell has looked patchy in his first three games back from injury and it would take a much improved showing against the Titans on Saturday to see him enter the selection frame.
Kata, meanwhile, has forged a potent combination with winger Manu Vatuvei over the opening seven rounds of the NRL and that could be enough to see him get the nod, although Penrith's Dallin Watene Zelezniak is another contender for the left flank position.
The Kangaroos have their own injury worries with Billy Slater (shoulder), Brett Morris (hamstring), Justin Hodges (hamstring), Darius Boyd (Achilles) and Josh Mansour (knee) all out of contention, while Josh Morris (ankle) and incumbent Dylan Walker (thumb) are still to prove their fitness and Sione Mata'utia is struggling for form.
Victory in Brisbane would see New Zealand usurp Australia at the top of the Rugby League International Federation's rankings and see them win more than two games in a row over Australia for just the second time in the game's 107-year history.
The Kiwis beat Australia twice in 1908 but only managed to better that when they won four consecutive matches between June 1952 and July 1953, giving them their only hat-trick of wins in 129 games against their rivals.