The Kiwis have four players on debut - Brad Takairangi, Nelson Asofa-Solomona, Isaac Liu and Danny Levi - and Kodi Nikorima and Shaun Johnson will play in the halves together for the first time.
Samoa's line-up mainly consists of players with previous test experience while they will be led by former Kiwis forward Frank Pritchard.
Both sides boast large forward packs and the result may well hinge on which side controls possession better and dominates in the middle of the field.
The Kiwis should have the edge in class but intrigue surrounds how well the men in blue will gel together in their opening hit-out and this contest could be closer than many are anticipating.
Our tip: Kiwis 22-14
Last RLWC meeting: 2013 - Kiwis 42-24 Samoa
Last test meeting: 2014 Four Nations - Kiwis 14-12 Samoa
Odds: Kiwis $1.20, Samoa $4.20
Kiwis: 1. Roger Tuivasa-sheck 2. Dallin Watene Zelezniak 3. Gerard Beale 4. Brad Takairangi 5.Jordan Rapana 6. Kodi Nikorima 7. Shaun Johnson 8. Martin Taupau 9. Thomas Leuluai 18.Jared Waerea-Hargreaves 13. Simon Mannering 12. Joseph Tapine 10. Adam Blair.
Interchange: 14. Nelson Asofa-Solomona 15. Russell Packer 16. Isaac Liu 17. Danny Levi
Reserves: 19. Peta Hiku 21.Addin Fonua-Blake.
Samoa: 1. Young Tonumaipea 2. Peter Mata'utia 3. Timoteo Lafai 4. Joseph Leilua 5. Ken Maumalo 6. Joseph Paulo 7. Ben Roberts 8. Junior Paulo 9. Jazz Tevaga 10. Sam Lisone 11. Joshua Papalii 12. Frank Pritchard 13. Leeson Ah Mau.
Interchange: 14. Pita Godinet 15. Herman Essese 16. Suaia Matagi 17. Bunty Afoa.
Reserves: 18. Zane Musgrove 19. Ricky Leutele.