In another key milestone for the Wallabies, Scott Sio will make his run-on debut at loosehead prop after a pair of impressive cameos from the reserves bench in Brisbane and Mendoza, and a strong training camp.
"We have been impressed with Scott since joining the Wallabies group and he has worked extremely hard to put himself in this position," said Cheika.
Matt Giteau returns from injury for his first start against New Zealand since 2011. The 93-Test veteran will join Bernard Foley and Tevita Kuridrani in the Wallabies midfield.
Dean Mumm's rise since returning from European Rugby continues, with the mobile lock moving in to the starting side to replace Will Skelton, who has been moved to the reserves bench for the first time this season.
Drew Mitchell will get his first opportunity in the Wallabies starting XV this international season, joining Adam Ashley-Cooper and Israel Folau in the Wallabies back three.
Australia and New Zealand both sit on nine competition points on The Rugby Championship table, with the match at ANZ Stadium this Saturday deciding the victor of the tournament for 2015.