However, his two most recent major championship experiences have ended in heartbreak.
At the 2008 Beijing Paralympics he collapsed with heat exhaustion in the final of the 5000m and subsequently failed to medal in the 800m and 1500m. Meanwhile, at the 2011 IPC Championships staged in Christchurch, where he was the New Zealand flag bearer, the Kiwi again failed to climb the podium after an Achilles problem.
He is hopeful of a better showing in London, where he plans to compete in both the 800m and 1500m.
"My goal is to win a medal," he says. "My training at the moment has given me a lot of confidence. I recently ran a 1m 56s (800m in Manchester, England) with my main target the 1500m.
"It is always hard to know how the North Africans are going because finding out results can be patchy. I was stung in Beijing by a Kenyan guy who took more than 20 seconds off the world record in the 5000m, so anything can happen."
Prendergast believes the decision to base himself in London - he lives in Edgware with his wife - for the past five years will pay dividends.
"The race opportunities have been a lot better over here, so that has been a real bonus.
"I also feel having spent so long in London it feels like a home games for me.