Flacco could not take advantage as Joe Haden got his second interception of the game in the end zone.
Flacco, however, redeemed himself with a 11-yard touchdown pass to Steve Smith. A two-point conversion on a slant to Kyle Juszczyk boosted the margin to 21-78 with 2:05 left in the third quarter.
On the Ravens' next possession, Breshad Perriman caught his first career touchdown pass on a 27-yard lob from Flacco that was upheld after a review.
Baltimore linebacker Terrell Suggs, who is playing with a torn biceps, forced a fumble on the Cleveland 30 to continue the misery for the Browns. Cleveland has been outscored 157-51 in the second half this season, including an overtime loss to Miami.
The Ravens now lead the all-time series 27-9. Baltimore, who relocated from Cleveland in 1996, have also won five of the past six games, including a 25-20 victory on September 18.