Ash Barty had never made it through to the final 16 at the Australian Open and she wasn't able to change that trend as she lost to Naomi Osaka on Saturday.
Novak Djokovic defeated Albert Ramos-Vinolas on Saturday night while Tomas Berdych advanced to the fourth round after overcoming Juan Martin Del Potro.
Angelique Kerber demolished Maria Sharapova and Roger Federer outclassed Richard Gasquet.
Lleyton Hewitt and Sam Groth also starred, defeating the third seeded doubles pairing in a stunning boilover in front of an adoring crowd.
ROD LAVER ARENA
(1) Simona Halep (ROU) defeated Lauren Davis (USA) 4-6 6-4 15-13
Hyeon Chung (KOR) defeated (4) Alexander Zverev (GER) 5-7 7-6 2-6 6-3 6-0
(21) Angelique Kerber (GER) defeated Maria Sharapova (RUS) 6-1 6-3
(2) Roger Federer (SUI) defeated (29) Richard Gasquet (FRA) 6-2 7-5 6-4
MARGARET COURT ARENA
Madison Keys (USA) defeated Ana Bogdan (ROU) v (17) 6-3 6-4
6-Karolina Pliskova (CZE) defeated (29) Lucie Safarova (CZE) 7-6 7-5
(5) Dominic Thiem (AUT) defeated (26) Adrian Mannarino (FRA) 6-4 6-2 7-5
Naomi Osaka (JPN) defeated (18) Ashleigh Barty (AUS) 6-4 6-2
(14) Novak Djokovic (SRB) defeated (21) Albert Ramos-Vinolas (ESP) 6-2 6-3 6-3
Su-Wei Hsieh (TPE) defeated (26) Agnieszka Radwanska (POL) 6-2 7-5
(8) Caroline Garcia (FRA) defeated Aliaksandra Sasnovich (BLR) 6-3 5-7 6-2
(25) Fabio Fognini (ITA) defeated Julien Benneteau (FRA) 3-6 6-2 6-1 4-6 6-3
(19) Tomas Berdych (CZE) defeated (12) Juan Martin Del Potro (ARG) 6-3 6-3 6-2
Hewitt, Groth are 'un-bloody-believable'
Lleyton Hewitt and Sam Groth pulled off a minor tennis miracle by knocking out the third seeded pairing of Horia Tecau and Jean-Julien Rojer in the second round of the men's doubles draw.
The unseeded Aussies did the damage with an unexpected 7-6 4-6 7-5 win in front of a packed crowd on Court 2.
Groth is playing his final tournament before hanging up the racquet and convinced Hewitt to come out of retirement and partner him at Melbourne Park. The 36-year-old has lost none of his touch nor his fighting spirit.
"This is amazing," Groth said of the parochial home support. "This is for sure what I'll miss."
Fed Express rolls on
He may have defeated Richard Gasquet in straight sets but the Frenchman made life difficult for Roger Federer on Saturday night.
The World No. 2 outclassed Gasquet 6-2 7-5 6-4 on Rod Laver Arena to advance to the fourth round, where he'll meet Hungarian Marton Fucsovics.
Dominant in the first set, the going only got tougher from there for Federer. The second went on serve and looked like heading towards a tiebreak until the Swiss broke late in the set and showed why he's a 19-time grand slam winner, icing the set by upping the ante in a clutch period.
The third set followed a similar pattern as Gasquet tried desperately to keep pace. But as well as he played, Federer was always able to bounce ahead when it mattered most and so it was as he closed out the final set 6-4.
'Pathetic' fault ruins Gasquet
Roger Federer cruised through the first set 6-2 against Richard Gasquet.
The Swiss maestro was aggressive on Saturday night, meeting the ball early from close to the baseline and often inside it, while at 3-2 up in the second he had already been to the net 17 times.
Midway through the set the umpire told both players Hawkeye was down and with Federer serving at 30-30 at three-all, the technological breakdown came back to haunt Gasquet.
A Federer ace off his second serve was called out but the chair umpire overruled the call. Gasquet was distraught, certain it was wide.
Jim Courier said in commentary the Channel Seven team had seen a replay and believed it "certainly looked wide".
Gasquet pleaded with the umpire but there was nothing she could do and Gasquet went on to lose the game.
Had the ball been called out, it would have been a double fault and handed the Frenchman his first break point opportunity of the match.
To make matters worse, Hawkeye was back in action just a few minutes later, but it was too late.
"Wow. With no Hawkeye, this — oh, this is hard to take for Gasquet," Courier said of the incident.
The tables were turned when Federer broke Gasquet just as the set looked to be he headed towards a tiebreak, then showed his class to close it out 7-5 and go two sets to love up.
"He (Federer) was lucky in that set that Hawkeye was broken," Courier said. "I'm not saying he would have been broken but he would have been in an uncomfortable position he hasn't had yet."
Djokovic wins through
Six-time champion Novak Djokovic has struck form to advance to the fourth round of the Australian Open, looking in excellent touch during a straight-sets routing of Spain's Albert Ramos-Vinolas.
The Serbian took a medical time-out during Saturday night's second set for treatment of an apparent hip complaint, but regrouped to claim a 6-2 6-3 6-3 victory in two hours and 21 minutes.
He will face world No. 58 Hyeon Chung in the fourth round after the South Korean youngster's five-set defeat of fourth seed Alexander Zverev.