The joint RFU and Premiership CMRG, comprising independent chairman Dr Julian Morris, RFU director of professional rugby Nigel Melville and Premiership Rugby director Phil Winstanley, was heavily criticised for failing to sanction Northampton over their mishandling of North's concussion against Leicester.
The same three men will now look into the incident involving Ioane with Sale - who are already fighting a court case against former scrum-half Cillian Willis for alleged mishandling of a concussion which forced him to retire in 2013 - set to answer more tough questions over their handling of the incident.
In September, Sale director of rugby Steve Diamond heavily criticised rugby's Head Injury Assessment, claiming 'all you need now is a slap on the head' to be removed from the field.
Speaking before the latest announcement, RFU chief executive Ian Ritchie on Friday defended the findings of the original CMRG investigation into the North case, which made nine recommendations around improving concussion education but stopped short of imposing sanctions.
'We are pretty much the only country in the world that has a review process around concussion,' Ritchie said.
'If we discover with the review group that there was some flagrant disregard of what should have happened, then I'm sure that will be dealt with, and the review group has an ability to sanction.'