It's also the worst possible timing. The Kiwis are on the verge of making history, aiming for what would be a quite incredible fourth successive victory against the Kangaroos. They have already been shorn of a number of key players, and the absence of Vatuvei and Matulino adds to the experience vacuum.
Kiwis coach Stephen Kearney may have elected not to pick the duo anyway, but in the usual scenario it would have been his decision to make alone, rather than having the option taken away from him.
Vatuvei was man of the match in the last two triumphs over the Kangaroos - with a particularly outstanding display in the historic Anzac test victory in Brisbane last year - and has been a rock for his country for more than a decade. And Matulino has been a Kiwis fixture for most of his career although Jesse Bromwich has overtaken him as the team's No1 prop.
And let's not forget Tonga (Konrad Hurrell and Albert Vete) and Samoa (Sam Lisone), who have also missed out on some of their premier players, for the Pacific test matches next Saturday. All three would have been certainties for the Island nations looking to build on the progress they have made over the past few years.