The forward pack remains unchanged after neither Dominic Bird nor Brodie Retallick was cleared to return from long injury lay-offs, leaving Taleni Seu to resume his partnership alongside the ever-present Michael Allardice.
There are three alterations to the reserves, with Tamanivalu taking his place on the pine alongside Maama Vaipulu and Shaun Stevenson, who will return to the 23 for the first time since sustaining a shoulder injury in round one against the Crusaders.
The Chiefs have fallen to the Brumbies in their last four clashes in Canberra and Rennie knows his side will face a fierce test if they wish to retain their lead at the top of the standings.
"It's always a big challenge going to Canberra and playing against the best Australian side," he said. "It'll be a test of us as individuals and a gauge as to where we're at as a group."
The Chiefs team to play the Brumbies in Canberra on Saturday night:
1. Mitchell Graham
2. Hika Elliot
3. Siate Tokolahi
4. Michael Allardice
5. Taleni Seu
6. Tom Sanders
7. Sam Cane (c)
8. Michael Leitch
9. Brad Weber
10. Aaron Cruden (c)
11. James Lowe
12. Charlie Ngatai
13. Anton Lienert-Brown
14. Toni Pulu
15. Damian McKenzie
Reserves: Rhys Marshall, Atu Moli, Siegfried Fisi'ihoi, James Tucker, Maama Vaipulu, Kayne Hammington, Seta Tamanivalu, Shaun Stevenson