"It means everything [playing for England], just knowing that everyone's behind you and supporting you - all of England and all the Samoan people as well," he said of playing in front of his many supporters. "Thank you to all of them for the awesome support."
Tuilagi speaks with an English accent because he moved to the country as a 13-year-old. He is one of seven brothers, six of whom are rugby players. Henry, Freddie, Alesana, Anitelea and Sanele are Manu's elders in the Tuilagi family and all have played for Samoa.
They are a remarkable sporting family but the young Tuilagi's ascent to the top has probably been the most dramatic. Two years ago he was at the risk of being deported because he had entered England on a six-month tourist visa and had stayed on.
As a 19-year-old the Home Office wanted him out before making a U-turn after a plea from his Leicester Tigers club and thousands of people who signed a petition.
He said then after receiving the good news: "I always wanted to stay in Leicester. I went to school in this area and my friends are here.
"It is a big day for me to be told this good news and now I can concentrate on my rugby career with Leicester Tigers."
Now he is the toast of England for putting the world champions to the sword.