They did a good job of staying in touch with the visitors before a couple of mistakes - the result of poor option-taking around the shooting circle - allowed the Vixens to stretch out their lead in the final couple of minutes before the first break.
Leading 17-12 at the first break, the Vixens seized the momentum early in the second spell after racking up 11 unanswered goals.
With the Tactix feeders unable to find a way past the Vixens' star defensive pairing of Geva Mentor and Bianca Chatfield, the visitors snared a wealth of turnover ball, which was clinically converted into points down the other end of the court - Karyn Bailey and Tegan Caldwell missing just one shot at goal between them in the first half.
Heading into the third quarter the Vixens looked well in control of the match with a 36-21 lead.
But the Tactix proved they weren't done with yet, opening the period with a run of six goals, while keeping the Vixens scoreless for nearly six minutes as the shooters struggled to adjust to the new defensive pairing of Jane Watson and Zoe Walker.
Midcourters Jade Clarke also started the third quarter with a lot of energy, pitching in with a couple of crucial steals.
While the Vixens struggled to rediscover their speed and timing on attack, their defence end continued to provide them with a steady flow of ball, allowing the visitors to restore a 45-31 lead heading into the final period after a low-scoring quarter.
After their third quarter hiccups, the Vixens rediscovered their spark in the closing spell, with the Tactix defence unable to keep up with the speed of the Melbourne attack.
The Vixens landed an impressive 22 goals in the final spell, as Caldwell and Robinson ran rings around the defence.
Last night's other game between the Pulse and the Swifts in Sydney was too late for this edition.