With the Magic as equally eager to notch a vital victory, the Mystics struggled to gain momentum in the opening quarter of the clash.
With the accurate Lenize Potgieter - who netted 100 per cent of her shots last week - back on the court in threatening form, it was up to a strong Mystics defence line-up to limit the South African shooter's impact.
And although the Mystics looked promising to take an early lead, shooters Bailey Mes and Jamie Hume's hesitancy under the hoop saw the visitors slip behind an ignited home side.
Stepping on to the court in the second quarter, Mystics captain Anna Harrison looked desperate for her side to rediscover the form they showed earlier in the season.
Harrison's tenacious defence paired with the fresh skillset of goal shoot Tera-Maria Amani to kickstart a sudden six-goal run as the Mystics suddenly surged ahead to lead 28-24 at halftime.
Dominating the third quarter, the Mystics made a decisive impact on the scoreboard, leaving the home side with plenty of ground to make up. The Magic briefly clawed back lost ground, but it was too little too late as the Mystics held their nerve to secure the win.
The Tactix and the Central Pulse will tip off Round 12 on Sunday afternoon in the season's final Super Sunday event at Takanini's Pulman Arena.
Super Sunday will also host the final match of the Northern Challenge where the Mystics will have a shot at redemption, and a chance to further enhance their playoff hopes, when they take on the Stars.