Braun, injured New York Yankees star Alex Rodriguez and more than a dozen other players were targeted by MLB following a report by Miami New Times in January that they had been connected with Biogenesis of America, a now-closed anti-aging clinic.
"For these guys still to be involved with this stuff just baffles me," Miami Marlins manager Mike Redmond said. "The education's there and everybody knows what you can and can't take. It baffles me that this continues to be a black cloud over the game. I know Major League Baseball's done a great job of cleaning up the game and the testing policy and all that. And it's working. But at the same time, too, it seems like we'll go through a lull and then, bam, here comes another guy that gets suspended. It's got to stop."
Braun will miss Milwaukee's final 65 games without pay, costing him about $3 million of his $8.5 million salary. With the Brewers in last place in the NL Central, they aren't likely to have any playoff games for him to miss.
"I wish to apologize to anyone I may have disappointed," Braun said. "I am glad to have this matter behind me once and for all, and I cannot wait to get back to the game I love."
Under the agreement reached by MLB and the players' association the specifics of Braun's admission were not made public.
A person familiar with the deal, speaking on condition of anonymity because no statements were authorized, said 50 games of the penalty were connected to Biogenesis. The additional 15 games stemmed from Braun's actions during the grievance that overturned his positive test from October 2011. The suspension will count as a first violation of the drug program, the person said.
Union head Michael Weiner said last week that arbitration hearings for players contesting suspensions likely would not start until September, which would delay any penalty until next season. But he also indicated the union would urge players to make a deal and get a suspension over with if there was strong evidence of guilt.
"I am deeply gratified to see Ryan taking this bold step," Weiner said in a statement. "It vindicates the rights of all players under the joint drug program. It is good for the game that Ryan will return soon to continue his great work both on and off the field."
The 29-year-old Braun was hitting .298 with nine homers and 38 RBIs this year, slowed by a thumb injury that limited him to one game between June 9 and Friday. He was at Miller Park before Monday's game against San Diego and addressed the Brewers, then left without speaking to reporters.
Braun met with MLB investigators in late June. Baseball's probe was boosted when Anthony Bosch, who ran Biogenesis, agreed last month to cooperate with the sport's investigators.
By serving the entire penalty this year, Braun gains a slight monetary advantage. His salary increases to $10 million next year, when a 65-game suspension would cost him about $500,000 more.
Negotiations over penalties for other players haven't begun, according to a second person familiar with the probe, also speaking on condition of anonymity because no statements were authorized.
Rodriguez admitted using performance-enhancing drugs while with Texas from 2001-03 but has denied taking them since.
A three-time AL MVP, Rodriguez has been sidelined all season following January hip surgery and was hoping to be called up to the Yankees this week, although he injured a thigh playing in the minor leagues and is out beyond Wednesday.
Baseball was criticized for allowing bulked up sluggers to set power records in the 1990s and only started testing in 2003. Since then, testing and penalties have become more stringent and last year San Francisco's Melky Cabrera was suspended for 50 games, just weeks after he was voted MVP of the All-Star game.
Four All-Stars this year have been linked in media reports to Biogenesis: Texas outfielder Nelson Cruz, San Diego shortstop Everth Cabrera, Oakland pitcher Bartolo Colon and Detroit shortstop Jhonny Peralta.
Other players reportedly tied to Biogenesis include Cabrera, now with the Toronto Blue Jays, Yankees catcher Francisco Cervelli and Seattle catcher Jesus Montero.
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AP Baseball Writer Janie McCauley in San Francisco, AP freelance writers Mark Didtler in Tampa, Fla., Joe DiGiovanni in Milwaukee and Mike Kelly and Jack Etkin in Denver contributed to this report
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