First appearances for the Blues also loom for Ronald Raaymakers, Jamison Gibson-Park, Marty McKenzie and Albert Nikoro who have been named in the reserves.
The Blues have rattled the New Zealand conference with wins against the Hurricanes and Crusaders to start this Super 15 campaign.
Those results have not curbed Kirwan's capacity to experiment with the new talent in his squad.
He wants to create strong competition for places and look after his players and even though the Blues have a bye next round, he reasons this is the time for adjustments.
It is an intriguing concept which should take the attention on the Blues to another level on Sunday.
Blues: Charles Piutau, Frank Halai, Rene Ranger, Francis Saili, Waisake Naholo, Baden Kerr, Piri Weepu, Steve Luatua, Luke Braid, Kane Barrett, Liaki Moli, Ali Williams ©, Charlie Faumuina, Quentin MacDonald, Tim Perry. Reserves: James Parsons, Angus Ta'avao, Ronald Raaymakers, Brendon O'Connor, Jamison Gibson-Park, Marty McKenzie, Albert Nikoro.