Lee was three over for his third round when he made his way to the par-four last and left himself a four-footer for par at the 18th, which he knocked so far past the hole that he left himself a longer putt coming back for bogey.
His next effort failed to reach the hole and his third putt - his sixth shot - then rattled nearly seven feet past the target, with Lee's following attempt finishing just under four feet from the cup.
The world No 108 saw his eighth shot go further past the target than any of his previous efforts, before eventually holing from seven feet seven inches - the longest putt of the lot - to finish his round with a quintuple-bogey nine.
The six-putt from four feet saw Lee close out an eight-over 78 and 13-over for the tournament. By withdrawing he gave up any prizemoney for the event with last-placed earning US$24,725.
Lee last withdrew from a tournament in 2017, when he pulled out of the BMW Championship near Chicago after just two holes citing a lower-back complaint following a birdie and a bogey.