Joining Spurs in the next round were fellow English travellers Newcastle, who thanked Shola Ameobi's third European goal of the season for a 1-0 win at Metalist Kharkiv, the Ukrainians who held the Magpies to a goalless stalemate last week.
Newcastle were under the cosh for much of the match and Dutch keeper Tim Krul made several top-drawer saves, before Ameobi struck on 64 minutes for a crucial away goal.
And despite late pressure from the Ukrainians - Brazilian striker Willian hitting the post - Newcastle, whose last trophy came in the old Fairs Cup - predecessor of the defunct UEFA Cup, back in 1969 - held on to advance as Kharkiv suffered only their second defeat in 12 outings at the Metalist Stadium.
Also on Wednesday, Russia's Rubin Kazan put out holders Atletico Madrid 2-1 on aggregate despite Falcao giving the Spaniards the win by the only goal on the night.
Inter, European Cup winners in 2010, went through after a 3-0 romp at 10-man Romanians Cluj for a 5-0 aggregate success.
Colombian star Fredy Guarin scored a brace for Inter with Marco Benassi adding the third.
Elsewhere in early action, Germany's Stuttgart won 2-0 at Belgium's Genk for a 3-1 aggregate win, while Italy's Lazio defeated German rivals Borussia Moenchengladbach 2-0 with Antonio Andreva and Alvaro Gonzalez the scorers in the first half as the Romans progressed 5-3 overall.
FC Basel of Switzerland went through 3-1 on aggregate after a 1-1 draw with Ukrainian outfit Dnipro.
- AAP