However, Mancini insisted that there will be no let-up from his players, with London rivals Chelsea and Tottenham Hotspur both in a position to claim the runners-up spot should City take their foot off the pedal.
"It is over but it doesn't change anything because we have to do our best to the end,'' Mancini said.
"We should try to play well and win all the games, and we also have the FA Cup semi-final (against either United or Chelsea).
"We have Chelsea four points behind and Tottenham five points behind. For this reason it is important that we have to keep working hard and well.
"We know that in football it is difficult to win the title for the second year. But we still have the FA Cup and can get second position.''
Mancini, whose side begin the last leg of a frustrating season against Newcastle United at the Etihad Stadium on Saturday, gave no interviews after the defeat by Everton that ended the slim hopes of a recovery in the title race.
He admitted: "I didn't want to say any bad things. I was disappointed, I was really upset.
"In the end we shot 22 times at goal and did not score. We have that as a problem. This is the problem we have had this year - we don't score enough goals.''
But the manager is sure that his disappointed players will have the mentality and attitude to finish the campaign with their heads held high.
He said: "When you are a top team with good players, you should be very strong whether you win or lose.
"When you can't win a title, you have another situation that you can improve. It's very important that we do our best for the next nine games.''
-AAP
