This was a crushing defeat to a Tottenham side managed by Jose Mourinho, who was fired by United in 2018 to make way for Solskjær. It came against a Tottenham team that has played eight games in 22 days across three competitions and was trailing after two minutes at Old Trafford.
But after Bruno Fernandes' penalty, United's wretched defence allowed Tanguy Ndombele to level in the fourth minute and Son Heung-Min to net again inside three minutes.
United can be aggrieved that Erik Lamela's apparent play acting led to Anthony Martial being sent off in the 28th minute. But the team was already being run ragged by Tottenham.
Harry Kane scored his first on the half-hour, Son netted again in the 37th, Serge Aurier was on target in the 51st and Kane wrapped up the rout from the penalty spot in the 79th.
Former Manchester United Patrice Evra slammed the performance at halftime on Sky Sports UK.
"Are you seeing this right now? I don't even want to comment on this game. It's catastrophic. My advice to Man Utd fans? Buy a PlayStation, buy Sancho and even Messi. No one in this team deserves to play," the former French defender said.
Eight-time Olympic gold medalist and Manchester United fan Usain Bolt wasn't impressed either, saying on Twitter: "I don't know this feeling. Refuse to accept this feeling or to even get use to this feeling."
Liverpool's heavy defeat came as an even bigger shock.
Ollie Watkins scored a hat trick and Jack Grealish scored twice as Villa made it three wins out of three after only surviving in the league on the last day of last season.
Liverpool became the first reigning Premier League champions to concede seven in a game. The last time it happened in English football's top division was in 1953.