Guardiola has played Sterling in that role in the past. He has even used Bernardo Silva there but Aguero was missed against Chelsea. Not just because of his individual chance conversion rate but because of the overall effect of him being in the team.
Aguero has eight goals in 13 league appearances this season but, crucially, with him in the side, City's conversion rate is 15.69 per cent, second only behind Arsenal in the Premier League.
Without Aguero, City are at 11.11 per cent, which puts them below Brighton, West Ham and Bournemouth, along with the other five of the 'Big Six'.
The good news for City is that Aguero is expected to be fit for Sunday's home game against Everton.
The other good news for City is that despite losing to Chelsea, in their opening eight away games, they have played Arsenal, Tottenham, Liverpool and have now been to Stamford Bridge. Of the 'Big Six', they have only to travel to Manchester United.
The good news for everyone (bar City fans) is that after Guardiola's first league defeat of the season, it appears there will be a title race, even if the holders remain clear favourites.
Liverpool are top and in that fight. Can Chelsea force their way in? Probably not.
City did not play poorly. They were sublime in the first half but they did miss Aguero. It is the kind of comment that infuriates managers, not least Guardiola. "Nobody knows," he said when asked whether his team would not have lost with the striker.
And of course he is right. It is hypothetical. But there is a weight of evidence.