Forest went above the threshold by £34.5m.
The club launched on appeal on two grounds - that the commission failed to regard the £47.5m sale of Brennan Johnson soon after the three-year assessment period ended as a mitigating factor and that some or all of the points deducted should have been suspended.
“Each of these grounds was rejected by the appeal board, which found the independent commission was entitled to immediately impose the sanction it did,” the Premier League said in a statement. “The four-point deduction will therefore remain in place.”
Forest still have to play Chelsea at home and next-to-last Burnley away, and would be guaranteed to stay up if they pick up at least four points from those matches.
Much of Forest’s mitigation effort centred around the club’s attempts to sell Johnson, one of their top players, after last season finished. Forest realised they were going to be in breach of the rules and needed to sell him or another valuable player by a June 30 deadline for any transfers to be included in the figures for the three-year financial assessment period.
Forest rejected bids for Johnson from Atletico Madrid and Brentford on or before June 30 and wound up selling him to Tottenham on September 1. By then, the club were in breach of the rules.
The three-person appeal board did not regard Forest holding out for a higher fee for Johnson as a mitigating factor, saying “it was a matter for the club how it managed its affairs in a compliant way”.