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"Based on the information that is currently available, all other Six Nations matches are set to go ahead as scheduled. As previously stated, Six Nations fully intends to complete all 15 games across all three championships when time allows. We will refrain from making any rescheduling announcements while we keep assessing the situation.
"Six Nations will continue to monitor developments with our unions and their respective governments and health authorities."
The decision to postpone a second Six Nations game comes after an Italian government decree issued on Wednesday night said Serie A matches would not be open to the public until April 3 in an attempt to halt the spread of Covid-19.
Italy is the European country most affected by the coronavirus, with more than 3000 people infected, and over 100 deaths.
Organisers considered the option of playing the game behind closed doors or delaying it until later in the year.
The Italian Rugby Federation is, however, desperate not to lose revenue generated by a lucrative home fixture with Eddie Jones' side.
Doubt also remains over whether France's final round match against Ireland in Paris next week will go ahead.
While intentions are to reschedule these games, the reality of doing so in a congested rugby calendar will be challenging, with the most likely opening not appearing until October.
With three wins from three and two rounds remaining, France leads England and Ireland by four points.
Outside the World War I and II years, the only incomplete Championship since 1898 was the 1972 Five Nations, when Scotland and Wales refused to play in Lansdowne Road because of the Troubles.