It will be the 31-year-old Wilder's fifth title defence, and his ninth pro fight in the state of Alabama.
'I'm excited about defending my world championship for a fifth time,' said Wilder.
'It's always fun to display my talents in front of the hometown fans. It's an opportunity that I always look forward to and it brings out the best in me. I'm healthy and I'm ready to put on a fantastic show.'
Meanwhile his challenger Wawrzyk, who has only lost once, said: 'I'm extremely motivated to fight for the heavyweight title against a great fighter like Deontay Wilder.
'Fighting for the world title has always been my dream. To fight against such a great athlete as Wilder is an extremely difficult challenge, but one I am ready for. I have trained for this since I was a teenager.
'On February 25 I will step into the ring ready to fight and win against the most dangerous man on the planet.'
Should Wilder come through this defence and Joshua beat Wladimir Klitschko on April 28 and defend his IBF heavyweight title at Wembley Stadium then a possible unification fight could move a step closer for later in 2017.
Parker is likely to have to wait in line until after that bout but could fight the winner in a full unification showdown that will be a huge pay day for the Mangere-born boxer.