After putting Ortiz down in the fifth round, Wilder was on the receiving end of a barrage of punches at the end of the seventh, and was lucky to survive to the bell.
To his credit, he recovered well after pacing himself through the eighth and ninth and in the 10th that renowned power in his right hand sent down the big Cuban twice, the second time with a big uppercut for the victory.
In a chaotic aftermath, and after he declared himself "the most dangerous man in the world" and the "baddest man on the planet", the American was asked whether Parker could beat Joshua.
"I think Parker has 100 per cent got a chance of winning that fight," he said. "He's just got to be smart and stick with the game plan.
"This game is not about how much a person weighs, it's not about how big a person's muscles are, it's all about that heart they're going to bring to the fight. You've got to believe in yourself."
Wilder's belief was incredible. Ortiz, 38, had a far longer amateur career than Wilder and the southpaw created problems for the champion with his head movement and ability to duck the heavy artillery coming his way.
But as we have seen so often in his career, Wilder, 32, has the ultimate get-out-of-jail card in his right hand and it saved him again.
He received more punishment in this fight than in any other, but still won with another knockout, his 39th in 40 professional fights.