The wayward James O'Connor (suspended), France-bound Digby Ioane, Fiji-born Brumbies flyer Henry Speight (ineligible), Dom Shipperley (shoulder) and Rod Davies (knee) are also unavailable.
Australia's wing dramas had already forced coach Ewen McKenzie to move Adam Ashley-Cooper from his preferred position at outside centre for the last-start 54-17 win over Argentina.
McKenzie could move Israel Folau to the wing instead of Betham and elevate fellow Waratah Bernard Foley to fullback but that's unlikely after the All Blacks successfully limited Folau's wing opportunities in the 47-29 and 27-16 Bledisloe losses in August.
A 2006 Australian Schoolboys representative, Betham's meteoric rise comes after failed stints with the Brumbies, Waratahs and Melbourne Rebels from 2008 to 2011. The 24-year-old turned his career around with an eye-catching 2012 season with Tasman in the ITM Cup.
The Wallabies included another New Zealand-born back in their travel squad with radar-boot Mike Harris likely to be picked as a reserve.
- AAP