Ja Morant led Memphis with 32 points and eight assists, and Dillon Brooks added 24 points. Brandon Clarke had 13 points and 12 rebounds off the bench. Desmond Bane scored 17 points and Jaren Jackson Jr. had 12.
Adams played 24 minutes with three rebounds and three assists.
Memphis tied the franchise record by winning 56 games in the regular season and earning its highest seed ever. The Grizzlies had a packed FedExForum for only their third Game 1 in Memphis. But they struggled early after a week off and led only twice by two, the last midway through the second quarter.
In this matchup of the NBA's top-scoring offenses and two of the league's youngest teams this season, the Timberwolves set franchise records for points in both the first quarter and the game. They also stymied Memphis with their 3-point shooting, rebounding and defense.
The Timberwolves looked like a team that played Tuesday night needing a win to clinch its seeding. They opened with a 9-2 run and led by as much as 13 before a 41-33 lead for the franchise's highest-scoring first quarter in the playoffs.
Minnesota led 65-62 at halftime, then outscored Memphis 32-30 in the third for a 97-92 lead going into the fourth quarter.