Her compatriot John Korir won the men’s race in 2:02:44.
Chepngetich set a blistering pace from the start, running the first 5km in 15 minutes flat and by the halfway mark had built a 14-second cushion between herself and Kebede.
Television commentators were astonished as she ground through the course, comparing her attempt at a sub-2:10 marathon to the moon landing, and she only seemed to gain momentum as she sprinted through the final two miles.
Chepngetich, the 2019 world champion, hunched over in utter exhaustion after breaking the tape and dedicated her performance to compatriot Kelvin Kiptum, who broke the men’s world record a year ago in Chicago and died in a car crash four months later.
“World record was in my mind,” she said. “Chicago, as I said in the press, is like home.”
The day began with a moment of silence at the starting line for Kiptum, who ran last year in 2:00:35, as runners took off under pristine conditions in the Windy City.
Korir stuck with a crowded men’s lead pack through the first 30km before making his move and was nearly 30 seconds clear of the rest of the field by the 35km mark.
He glided through the final kilometres, holding his arms out wide as he finished his textbook performance in a personal best time for his first major title.
Ethiopia’s Mohamed Esa was second in 2:04:39 while Kenyan Amos Kipruto (2:04:50) finished third.
“Today I was thinking about Kiptum,” said Korir. “I had to believe in myself and try to do my best.”