A number of world and Olympic champions and medallists have been confirmed for Saturday's meeting, an IAAF World Challenge event.
Word Indoor 60m silver medallist Nesta carter of Jamaica, Trinidad and Tobago's Olympic silver medallist Richard Thompson, Commonwealth Games champion Lerone Clarke, World Championships relay gold medallists Dexter Lee and Michael Frater, Darvis Patton and Antiguan Daniel Bailey were expected to chase Bolt in the 100m.
Blake who ran the second fastest 200m ever - 19.26 seconds last year - was originally expected to clash with former 100m world record holder Asafa Powell in the half lap race.
But Powell said on Wednesday a nagging groin injury had him re-evaluating his plans to start in the 200m.
Norway's Jaysuma Saidy Ndure, Rasheed Dwyer and Nickel Ashmeade are likely challengers in the 200m field.
The female sprints should be competitive with defending Olympic champion Shelly-Ann Fraser-Pryce, 100m world champion champion Carmelita Jeter, Bianca Knight, joint Olympic silver medallists Kerron Stewart and Sherone Simpson, Debbie Ferguson McKenzie and Kelly-Ann Baptiste all confirmed to race in either the 100m or 200m.
America's Jeter won the 100m last year and has the fastest 200m in the world this year of 22.31 seconds, clocked in California last month.
Sanya Richards Ross will headline the women's 400m, where she will go up against Britain's Christine Ohurugo as well as Jamaicans Novlene Williams Mills, Rose-Marie Whyte and IAAF Diamond League 400m hurdles winner Kaliese Spencer.
-AAP