Tour Odeon, which will house 36 more luxury flats, will be Monaco's first skyscraper since Prince Rainier banned tall buildings on the shoreline to avoid overshadowing the city.
Instead he encouraged the development of wider, lower buildings built on an extension into the sea. His decision was reversed in 2009 by his son and successor, Prince Albert, and plans for the 170m Tour Odeon were drawn up.
One in three of Monaco's 38,000 residents is a millionaire, according to a study by Spear's magazine and WealthInsight.
Irene Luke, of Savills, the estate agency, who moved to Monaco in 1990 from London, said it was becoming increasingly popular with wealthy Britons.
"It's becoming more and more like London by the sea."
Tax changes in some areas of Switzerland are also "making Monaco look like a very safe, stable place".
The penthouse is expected to go on the market next year. So far, 26 flats have been sold.
Sky-high price
World's costliest apartment: Penthouse of Odeon Tower, Monaco
• $475 million.
• 3251sq m apartment over five floors.
• Property will include infinity pool, private chauffeur, caterer and three staff bedrooms.
Watch a promotional video for the Odeon Towers project here: