It showed both the change in the relationship between the two countries and the greater emphasis the Barack Obama Administration had placed on the Asia Pacific.
"To make a stop in New Zealand is no small effort, so for people who have looked for signs of an improvement in the relationship, this is clearly one of them."
Dr Ayson expected discussions to include the next steps under the Washington Declaration.
"It's very clear that document is designed to encourage further development in the US-NZ relationship and that relationship has come quite a long way in quite a short time."
Just before the Washington Declaration was signed, US Marines visited New Zealand and a week afterwards New Zealand took part in the biennial Rimpac exercise at Pearl Harbour for the first time in 28 years.
However, its naval vessels were not allowed to dock at the military port, and instead had to berth at Honolulu.
Mr Panetta will go to Japan and China on his way to New Zealand, and Dr Ayson expected regional security to be discussed, including a dispute between China and Japan over an island chain in the East China Sea.
Mr Panetta will meet Dr Coleman and Foreign Minister Murray McCully and lay a wreath at the Hall of Memories in Auckland to commemorate those who died in World War II, as well as Korea, Malaya-Borneo, Vietnam and, most recently, Afghanistan.
Mr Panetta's is the latest in a string of visits by high-powered politicians in the Obama Administration in recent years, including Secretary of State Hillary Clinton and the Secretary for Homeland Security, Janet Napolitano, in May this year.
Mrs Clinton and Prime Minister John Key signed the Wellington Declaration during Mrs Clinton's visit.