The crash has resulted in serious delays in the area for motorists, police said. SH2 is expected to remain closed for several hours.
The serious crash unit is investigating the incident and diversions are being arranged.
"They are challenging so we ask that motorists avoid the area where possible and are patient if they experience delays," the spokesperson said.
Further south in the King Country, one person has died after a car rolled on Waitete Rd/State Highway 30 in Te Kuiti.
Police said the car rolled near Cotter St shortly before 9pm.
The person died at the scene and two others have been taken to hospital in moderate conditions.
The serious crash unit is investigating and the road is closed for now.
Diversions are in place and police have asked motorists to be patient in the face of delays because the road is expected to remain closed for some time.