Two people have been freed from their cars after an accident involving a truck and trailer and two cars on SH1, Wellsford.
A fire communication spokeswoman said they had three fire trucks at the scene, and they had extracted the two patients.
Police said they were notified of the incident at 2.27pm; they were currently in attendance at the scene.
One person has been airlifted to hospital with critical injuries. A second person is in a serious condition.
Part of SH1 remains closed.