At 4.23am, one minute after the previous callout, St John Ambulance was then dispatched to an incident on nearby Tapora St. One ambulance responded, treating two patients in a serious condition.
Police said they received a report of a "disorder in a business premises".
Officers were seen responding at the Adina Apartment Hotel Auckland Britomart.
Also overnight, one person was taken to hospital following reports of a serious assault in South Auckland.
The incident is believed to have occurred around 1.30am on Roscommon Rd in Wiri.
St John Ambulance sent three vehicles to the scene and one person was taken to Auckland Hospital in a critical condition, authorities said.
Inquiries into that incident also are ongoing, a police spokesperson said.