Police have already seized a large amount of synthetic drugs from addresses in the Hutt Valley and wider Wellington district and have arrested a number of people.
Eleven people have been admitted to Wellington Hospital in the past week and a half due to suspected synthetic drug use, including four people admitted over the space of 24 hours.
Kapiti-Mana Police said emergency services needed to be called four times between Tuesday and Wednesday afternoon.
Detective Senior Sergeant Grant Ferguson said each patient was believed to be affected by synthetic drugs.
He urged anyone using these drugs to stop immediately and contact their GP or the Alcohol Drug Helpline for help.
Hutt Valley Area Commander, Inspector Sean Hansen emphasised it was up to the coroner to determine how the Hutt Valley man died.
He urged anyone with information about synthetic drugs to contact police locally, or to do so anonymously via Crimestoppers on 0800 555 111.