"There has been plenty of recent media coverage of the health risks of consuming this product and we are concerned that there could be such a large amount potentially readily available in the community."
He urged any friends and family members to contact police if they knew of anyone who may have come into possession of synthetic cannabis either cheaply or for free.
"We want to get this off the street ... the amount of it is a real concern," Det Sgt Hanna said.
Police confirmed they had CCTV footage of the aggravated robbery, and were not ruling out one of the offenders may be a female.
The pair were both described as being 167-173cm tall, of medium to solid build, and were both believed to be Caucasian.
They were last seen leaving on foot in a northerly direction, he said.
Anyone who knew the identity of the offenders or who was in the vicinity of the Willowbank Dairy at the time of the incident was asked to contact Dunedin police on 471 4800, or provide information anonymously on the Crimestoppers line on 0800 555111.