Their parents were also injured and have been taken to North Shore Hospital.
A section of SH16 is closed as police Serious Crash Unit investigators carry out a scene examination.
"The information from the scene at this point in time is that a car with three children in the back has pulled out of a driveway near the crest of a hill and has collided with an oncoming car," said Waitemata police spokeswoman Beth Bates.
"At this point their condition is not known," she said.