Shortly after 5pm, the spokeswoman said two rescue helicopters, from Garden City Nelson and Garden City Greymouth, were both at the scene.
There were reports of serious injuries and two people were to be taken to hospital, she said.
The spokeswoman said the aircraft locator beacon was activated about 3.30pm, and there were also distress calls from the aircraft.
"A Murchison helicopter was first on scene, and two rescue helicopters, Garden City Nelson and Garden City Greymouth, were also dispatched."
By 6.30pm, the two rescue helicopters had transferred two passengers with serious injuries to Nelson Hospital, she said.
The matter has now been referred to the Civil Aviation Authority.
A man working at Murchison Helicopters said he understood the occupants had survived the reported crash.
"They're alright," he said.
A police spokeswoman said they were aware of the mayday call but their services were not required at this stage.