Diversions were in place and motorists advised to expect delays if travelling in the area.
A Hato Hone St John spokesperson said they were notified of a motor vehicle incident on Onehunga Harbour Rd at 7.35am.
“We responded with two ambulances and a rapid response vehicle.
“On scene, we treated two patients and transported them both to Auckland Hospital – one in a critical condition and one in a moderate condition.”
Waka Kotahi NZTA said the Neilson St off-ramp closed due to the crash.
“Delay your journey or allow extra time to use the alternative off-ramp at Queenstown Rd.”
Auckland Transport said travel on several bus routes was affected due to the crash.
The off-ramp reopened at 11.30am.