The cause of the crash was still under investigation.
Kawakawa fire chief Wayne Martin said firefighters used cutting equipment to free the car driver. Paihia brigade also responded but was not required.
Traffic was diverted around the crash scene with the highway reopened by daylight.
A St John spokeswoman confirmed one ambulance and one helicopter responded to the crash at 12.11am.
One patient was in a critical condition.
St John personnel treated him then started transporting him to Bay of Islands Hospital by road.