At the molecular level it mimics the effects of calorie restriction, which is known to lengthen the lives of some animals but not humans.
Some preliminary evidence also suggests the compound could help prevent cancer and reduce the stiffness of arteries in older women. But there is little real-world data to support links between resveratrol intake and improved human health, the researchers point out.
The research involved 783 Italians aged 65 and over who were in the Ageing in the Chianti Region study from 1998 to 2009.
Regular urine tests were carried out to look for breakdown products of resveratrol and see if their levels were associated with reduced cancer, heart disease and death rates.
During the nine-year follow-up, 268 (34.3 per cent) participants died and 27.2 per cent of those free of heart disease at the start of the study had developed the condition.
Of the 734 men and women who had no signs of cancer at enrolment, 4.6 per cent were later diagnosed.
But wine buffs and lovers of dark chocolate should not lose heart, say the scientists whose findings appear in the journal JAMA Internal Medicine.
"It's just that the benefits, if they are there, must come from other polyphenols or substances found in those foodstuffs," Professor Semba said. "These are complex foods and all we really know from our study is that the benefits are probably not due to resveratrol."
-AAP