Police confirmed one person died and another is understood to have moderate injuries.
Motorists faced delays as traffic was diverted around the crash site. Diversions were in place while the Serious Crash Unit carried out a scene examination.
A police spokesperson said at edition time no further information was available.
The fatality is the first for June and has taken Northland's road toll to 12, compared to 20 this time last year.
The road death came the same day as police, Waka Kotahi, ACC, Ministry of Transport, Auckland Transport and WorkSafe jointly urged Kiwis to take care this long weekend.
Together they claimed driving to the conditions was key to staying safe on the road as people enjoyed the Matariki break.
Kane Patena, director of land transport at Waka Kotahi, encouraged drivers to plan ahead.
"It gets dark earlier, and the weather conditions can be trickier this time of the year. It only takes a split second to lose control in wet or icy conditions.
"Make sure you check your tyre tread and pressure, use headlights, and take extra care – it's simple, easy and helps save lives."
Police will have visible staff patrolling the country's roads daily over the long weekend.
Superintendent Steve Greally, director of the National Road Policing Centre, spoke of how the horror crash in Picton was in the back of police minds.
"Over the recent weekend, we again saw how devastating a mistake can be on the road. In one moment, seven lives were lost in the most horrific way and two people are still in hospital.
"We do not want to see anything like this happen again this coming weekend," he said.
"Police can't control the actions of every driver 24/7. Being safe on the road is something we all have to take responsibility for."
